KMID : 0620920230550081652
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Experimental & Molecular Medicine 2023 Volume.55 No. 8 p.1652 ~ p.1658
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Reversing pancreatic ¥â-cell dedifferentiation in the treatment of type 2 diabetes
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Son Jin-Sook
Cha In-Tae
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Abstract
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The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic ¥â-cell failure. The failure of ¥â-cells to compensate for insulin resistance results in hyperglycemia, which in turn drives altered lipid metabolism and ¥â-cell failure. Thus, insulin secretion by pancreatic ¥â-cells is a primary component of glucose homeostasis. Impaired ¥â-cell function and reduced ¥â-cell mass are found in diabetes. Both features stem from a failure to maintain ¥â-cell identity, which causes ¥â-cells to dedifferentiate into nonfunctional endocrine progenitor-like cells or to trans-differentiate into other endocrine cell types. In this regard, one of the key issues in achieving disease modification is how to reestablish ¥â-cell identity. In this review, we focus on the causes and implications of ¥â-cell failure, as well as its potential reversibility as a T2D treatment.
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KEYWORD
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Type 2 diabetes
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